Rad23 and dsk2 have been reported to be invo lved in duplication of the spindle pole body spb the yeast equivalent of mammalian centroso mes biggins et al 1996. Surprisingly ddi1 and dsk2 do not show any redundancy but the triple deletion shows a synthetic defect suggesting that rad23 has at least two different roles in cell cycle progression during g2 m in addition we found that these putative roles do not include a role in spb duplication or spindle dynamics in addition we show that a tetra ubiquitin chain is able to bind several ubl uba . The three yeast ubl uba proteins rad23 ddi1 and dsk2 bind both ubiquitin and the proteasome they are not essential for viability and some redundancy in terms of stabilization of ubiquitinated substrates has been shown suggesting that they may have overlapping functions here we showed that rad23 is indeed redundant with both ddi1 and dsk2 for cell cycle related roles. Dtic ada465609 role of rad23 and dsk2 in nucleotide excision repair and spindle pole body duplication item preview remove circle share or embed this item embed . book role of rad23 and dsk2 in nucleotide excision repair and spindle pole body duplication uploaded by janet dailey rad23 and dsk2 have been reported to be invo lved in duplication of the spindle pole body spb the yeast equivalent of mammalian centroso mes biggins et al 1996 surprisingly ddi1 and dsk2 do not show any